Eliminates skin flushing for most individuals. Clinically proven to have a favorable effect upon cholesterol by promoting healthy cholesterol within normal limits.The vitamin Niacin has an impressive track record of positive effects upon cholesterol levels that are documented in numerous clinical trials.
Very few niacin products have been subjected to clinical study. Well controlled clinical trials conducted at the University of Minnesota, Harvard University and the Russian Research Center for Preventive Medicine have demonstrated excellent bioavailability and patient tolerance of Endur-acin with less than 4% of patients discontinuing therapy due to side effects. Average daily dosages of 1500 mg of Endur-acin produced favorable effects on all lipid components, indicating positive effects in promoting healthy cholesterol.
Traditional, or common niacin usage has been limited particularly by so-called “nuisance” side effects including skin flushing associated with tingling and warmth. Endur-acin, owing to its unique extended release formulation, eliminates for most individuals the unpleasant skin flushing effect that occurs when taking niacin. Endur-acin utilizes a unique wax-matrix process that ensures uniform, continuous release of niacin from the tablet during its 6 – 8 hour transit time through the digestive system. This greatly reduces gastrointestinal upset and gut irritation associated with the buildup of localized concentrations of niacin and skin irritations associated with a rapid rise in blood levels.
Endur-acin is usually well tolerated in single doses of 500 – 750 mg. However, higher daily doses should be divided into a 2/day or 3/day regimen to minimize chance of side effects. Never exceed 750 mg in a single dose. Contraindications to niacin supplementation include gout, liver diseases including hepatitis, pregnancy, severe cardiac arrhythmias, and possibly diabetes. Use of any niacin for cholesterol levels should always be physician supervised.
|Brand: ||Endurance Products Co (More Products)|
|Size: ||200 Tablets|
|Dosage: ||1 Tablet daily|
7 Customer Reviews
Excellent product, inexpensive
This has worked better than anything else at lowering cholesterol and triglycerides. I had to laugh (sadly) when I read Michelle's post who said her husband tried it once and it didn't work. I can't image what he expected by taking a medication once. In 2 months my triglycerides went from 123 to 67 without any other dietary changes. I gradually went from 500mg to 1500mg per day. I take the sustained release which prevents the flushing and I only have very minimal itchy skin. Since large medical studies are only funded by pharmaceutical companies why would they spend $$$ studying a cheap method that works? Just like they don't spend money on funding studies to show how low-carb diets work better than drugs to lower glucose levels for diabetics they rather spend $$ on 'proving' their meds are the only thing that works.lipidologist
by Brian S Edwards MD
In my practice I gave up starting high dose or moderate dose statin in the statin naive patient.
I have received too many referrals to see patients who are convinced that they can't take statins because of muscle pain with starting high dose statin.
I usually give samples of crestor 5 mg a day or every other day. In six weeks I check their LDL-P or their non-HDL cholesterol depending on their insurance.
Individual patients respond very differently to statins and the first dose often has an amazing effect.
In practice I have found that Niacin is the second drug of choice.
1- Arbiter 6, 3 and 2 CIMT studies
2- Coronary Drug Project - decreased Total Mortality by 11% after 15 years.
3-Clas I and Clas II Angio studies
4- FATS First major study to document regression with Angios
5- HATS SUSTAINED RELEASE NIACIN 1,000 MG BID USED IN THIS STUDY- CIMT study
6-Compell study - only 1,000 mg of niacin needed with crestor.
7-FDA indication for regression of plaque in combination with clofibrate
8-Stockholm Ischemic Trial- Positive primary and secondary trial with clofibrate
ADA/ACC Consensus statement April 2008 p818
"The preferred agent to use in combination with a statin is nicotinic acid because there is somewhat better evidence for reduction in CVD event with niacin, as monotherapy or in combination, than there is for fibrates."
I was extolling the virtues of niacin with statin to a cardiologist when he told me it made him nauseous to hear it because he could never get his patients to ever stay on niaspan because of side effects.
I told him I had the same experience until I began using OTC sustained release niacin. I only use 500 mg bid with a low dose statin to avoid side-effects.
With a total nicotinic acid of 1,000 mg the patient gets the best bang for the buck with HDL-C.
At this dose elevated HgbA1C rarely occurs even in diabetic patients.
Liver enzyme elevation is quite rare.
The Compell trial showed Crestor 40 mg lowered ApoB by 39%, while Crestor 20/Niacin ER 1,000 lowered ApoB by 42%.
The Seacoast trial also shows a better benefit adding niacin than doubling the statin.
Why take Niaspan when Endur-acin costs only $70 for !,000 tablets when purchased over the internet.
I never have needed to switch to Niaspan to use high dose nicotinic acid because I will use zetia as a third drug rather than risk flushing with high dose Niaspan.
often come back to tell me they can't afford the crestor. I put them on simvastatin 10 to 40 mg for only $10 for 3 months therapy.
Thus many of my patients have done very well on simvastatin/endur-acin for $90 a year.
is documented in spreadsheets in my book: The Tubby Theory from Topeka.Physician
by Brian Edwards MD
I am a Board Certified Lipidologist. I have used endur-acin extensively with my patients for the last two years. I have documented this experience in my book, The Tubby Theory from Topeka published on 1-25-10 by Xlibris.
In combination with simvastatin I have had excellent results and show this in my book.Good
by John C.
Good product.Works for my mom
by K. Persaud
My mom has been battling her cholesterol for a while now and she has tried tons of things from flax seed to fish oil and this seems to work. You will need to take it for a couple of weeks before the results make themselves visible. Also, it is very, very affordable. One bottle can last for months on end and one bottle is really cheap. Some products cost twice as much, have half the amount of tablets, and less of a result. This one works and is reasonably priced.
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