From the Manufacturer:
Cardio Assurance® [Circulatory]. Your heart deserves some special attention from improved Cardio Assurance. This better blend of heart-protecting herbs and vitamins contains many of the same powerful nutrients, such as hawthorn berries extract, folic acid, and vitamins B6 and B12, along with some new heart-healthy ingredients, including red grape extract and trimethylglycine.
Hawthorn berries are full of flavonoids, which help support blood flow and circulation in the heart arteries. Folic acid, Vitamin B6 and Vitamin B12 work synergistically to metabolize homocysteine, an amino acid that, in high concentrations, may be toxic to the blood vessels. Red grape extract contains resveratrol, which helps maintain blood vessel tone, while trimethylglycine helps convert homocysteine into methionine, aiding the body in maintaining homocysteine levels already in the normal range. Cardio Assurance also contains the heart healthy amino acids l-arginine, taurine and l-proline.